Abstract
The quest for a licensed effective vaccine against malaria remains a global priority. Even though classical vaccine design strategies have been successful for some viral and bacterial pathogens, little success has been achieved for Plasmodium falciparum, which causes the deadliest form of malaria due to its diversity and ability to evade host immune responses. Nevertheless, recent advances in vaccinology through high throughput discovery of immune correlates of protection, lymphocyte repertoire sequencing and structural design of immunogens, provide a comprehensive approach to identifying and designing a highly efficacious vaccine for malaria. In this review, we discuss novel vaccine approaches that can be employed in malaria vaccine design.
Highlights
Novel Strategies for Malaria Vaccine DesignAugustina Frimpong * 1,2,3 , Kwadwo Asamoah Kusi 1,2, Michael Fokuo Ofori 1,2 and Wilfred Ndifon 3,4*
Specialty section: This article was submitted to Microbial Immunology, a section of the journal Frontiers in Immunology
Even though classical vaccine design strategies have been successful for some viral and bacterial pathogens, little success has been achieved for Plasmodium falciparum, which causes the deadliest form of malaria due to its diversity and ability to evade host immune responses
Summary
Augustina Frimpong * 1,2,3 , Kwadwo Asamoah Kusi 1,2, Michael Fokuo Ofori 1,2 and Wilfred Ndifon 3,4*. Specialty section: This article was submitted to Microbial Immunology, a section of the journal Frontiers in Immunology. The quest for a licensed effective vaccine against malaria remains a global priority. Even though classical vaccine design strategies have been successful for some viral and bacterial pathogens, little success has been achieved for Plasmodium falciparum, which causes the deadliest form of malaria due to its diversity and ability to evade host immune responses. Recent advances in vaccinology through high throughput discovery of immune correlates of protection, lymphocyte repertoire sequencing and structural design of immunogens, provide a comprehensive approach to identifying and designing a highly efficacious vaccine for malaria. We discuss novel vaccine approaches that can be employed in malaria vaccine design
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
