Abstract
The mechanisms governing development of diseases causing lower urinary tract disorders, such as overactive bladder and bladder pain syndrome/interstitial cystitis, remain unclear. Although several mechanisms have been proposed, currently available experimental models to investigate such mechanisms are insufficient. However, this situation could be set to change with the development of a novel rat model enabling investigation of the effects of stretch, electrical and pharmacological stimulation of the bladder in vivo and in situ.
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