Novel sound exposure drives dynamic changes in auditory lateralization that are associated with perceptual learning in zebra finches

Abstract

Songbirds provide a model for adult plasticity in the auditory cortex as a function of recent experience due to parallels with human auditory processing. As for speech processing in humans, activity in songbirds’ higher auditory cortex (caudomedial nidopallium, NCM) is lateralized for complex vocalization sounds. However, in Zebra finches exposed to a novel heterospecific (canary) acoustic environment for 4–9 days, the typical pattern of right-lateralization is reversed. We now report that, in birds passively exposed to a novel heterospecific environment for extended periods (up to 21 days), the right-lateralized pattern of epidural auditory potentials first reverses transiently then returns to the typical pattern. Using acute, bilateral multi-unit electrophysiology, we confirm that this dynamic pattern occurs in NCM. Furthermore, extended exposure enhances discrimination for heterospecific stimuli. We conclude that lateralization is functionally labile and, when engaged by novel sensory experience, contributes to discrimination of novel stimuli that may be ethologically relevant. Future studies seek to determine whether, (1) the dynamicity of lateralized processes engaged by novel sensory experiences recurs with every novel challenge in the same organism; (2) the dynamic pattern extends to other cortical, thalamic or midbrain structures; and (3) the phenomenon generalizes across sensory modalities.