Abstract
This work was undertaken to determine the structural characteristics of a novel polysaccharide, Sorghum Water-Soluble Polysaccharide (SWSP), extracted from Sorghum (Sorghum bicolor (L.)) seeds and to assess its in vitro hemolytic and antioxidant activities as well as its in vivo wound healing ability to treat burns induced by fractional CO2 laser. Results obtained by 13C, 1H and HSQC Nuclear magnetic resonance (NMR) indicated that SWSP showed the characteristic bands of polysaccharides. Scanning electron microscopy of SWSP showed a rough surface with numerous cavities. SWSP exhibited strong antioxidant activities determined through three different assays: ferrous chelating activity, reducing power and DNA nicking. Also, no hemolytic activity was detected towards human erythrocytes. On the other hand, the application of SWSP hydrogel on the burn site in a rat model significantly improved wound appearance and accelerated the wound closure after 8 days of induction. Histological assessment of biopsies also demonstrated complete re-epithelialized wounds with a full epidermal regeneration. Thus, SWSP hydrogel which was efficient on wound closure might be useful as a wound healing agent in modern medicine.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
