Novel Silver Nanocomposites as Effective Antitumor Agents

Abstract

AbstractNovel silver nanocomposites based on copolymers of N,N‐diallyl‐N'‐acylhydrazines and diallylaminophosphonium salts with N‐vinylpyrrolidone and sulfur dioxide have been developed. There have been conducted studies of the cytotoxicity of the synthesized copolymers and nanocomposites toward lung carcinoma A549, rhabdomyosarcoma RD TE32, melanoma MS, and non‐cancerous embryonic kidney HEK 293. The nanocomposites have a significant cytotoxic activity against tumor RD TE32 and MS cell lines. There is the absence of a cytotoxic effect with respect to non‐cancerous HEK293 cell line. This indicates a high selectivity of silver nanocomposites with respect to RD TE32 and MS cell lines. The mechanism of cytotoxic effect of nanocomposites is determined. The nanocomposites cause apoptotic death of tumor cells with chromatin condensation and the reduction of mitochondrial fluorescence. The newly developed nanocomposites may be considered as promising for developing drugs to treat malignant cancer tumors.