Novel route for Synthesis of Antihypertensive activity of Tetrazole analogues as a Carbamate and Urea Derivatives

Ramakrishna Vellalacheruvu

doi:10.19080/gjpps.2018.05.555653

Abstract

Novel route for Synthesis of Antihypertensive activity of Tetrazole analogues as a Carbamate and Urea Derivatives

Highlights

Tetrazole analogues have a potential pharmacological activity in medicinal chemistry division
Several Active pharmaceutical drug intermediates (API) of tetrazole derivatives played their role in pharmaceutical and agrochemical region
These compounds act as multidimensional biological active drug candidates such as inhibition of Angiotensin (AT1), Angiotensin (AT2) receptor (Hypertension), antifungal & antibacterial, corrosion inhibitor, anti-inflammatory, anticancer, antioxidant, antifungal, analgesic, Antiviral, protein-arginine deiminase inhibitor, antimicrobial, Anti allergic, dual Selective serotonin and Nor epinephrine Reuptake inhibitors (SSNRIs) and HIV inhibitors

Summary

Introduction

Tetrazole analogues have a potential pharmacological activity in medicinal chemistry division. Several Active pharmaceutical drug intermediates (API) of tetrazole derivatives played their role in pharmaceutical and agrochemical region. These compounds act as multidimensional biological active drug candidates such as inhibition of Angiotensin (AT1), Angiotensin (AT2) receptor (Hypertension), antifungal & antibacterial, corrosion inhibitor, anti-inflammatory, anticancer, antioxidant, antifungal, analgesic, Antiviral, protein-arginine deiminase inhibitor, antimicrobial, Anti allergic, dual Selective serotonin and Nor epinephrine Reuptake inhibitors (SSNRIs) and HIV inhibitors. Many Tetrazole analogs were available for treatment of hypertension, such as Losartan potassium, Valsartan, Irbesartan, Candesartan and Olmesartan medoxonil. These drugs played a vital role to inhibit Angiotensin converting enzyme. These drugs block renin-angiotensin system (RAS, enzyme) which is secretly produced in Kidney Figure 2: metabolically bioisostere for carboxy and amide functional groups

Materials and Methods

Experimental Methods