Abstract
RNA interference (RNAi) is a transformative technology with great potential to control, study or even protect insects and acarines through the knockdown of target gene expression. RNAi offers unprecedented levels of control, but fundamental to its successful deployment is the need to deliver ‘trigger’ RNA in an appropriate fashion giving due consideration to potential barriers of RNAi efficiency, safety, and the intended purpose of the knockdown. This short review focusses on recent innovations in RNAi delivery that are designed for, or could be adapted for use with, insect and acarine pests of medical or veterinary importance.
Highlights
D Introduction E The underlying principles of arthropod RNA interference (RNAi) and the common hurdles limiting RNAi T efficiency encountered by insects have been reviewed comprehensively elsewhere [e.g. 1P 6]
Trigger RNA should arrive intact at its target cell, whereupon it is readily taken up and escaping the endosomal system [9] to be efficiently diced into siRNAs before entering the RNAi pathway
As will be discussed below, many RNAi delivery vehicles are capable of entering the insect body at multiple entry sites, but not necessarily effectively
Summary
Title: Novel RNAi delivery systems in the control of medical and veterinary pests. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain
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