Abstract

Novel radioactive DELTA 4,9,11-estratrienes marked with iodine 125 or 131 having the formula I wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and acyl of an organic carboxylic acid of 2 to 12 carbon atoms, R1 is the reminder of an amino acid of the formula R1NH2 or a derivative thereof being marked with iodine 125 or 131 and the wavy lines indicate the -OR is in the alpha - or beta -position and the oximido group is in the syn or anti position, a process and intermediates for their preparation, antigens prepared therefrom and use thereof to prepare antibodies.

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