Abstract
Two novel series of pyrazole and thiophene-linked quinoline analogues via amide bond were conveniently synthesized and characterized by IR, NMR, and HRMS analysis. The synthesized compounds were evaluated for their antimicrobial, anti-inflammatory, and anti-leukemic activity. The antimicrobial evaluation of the target compounds clearly showed that compound 11c has better activity compared to other compounds against tested pathogens. The anti-inflammatory assay of the selected compounds showed that 12c with IC50 value 118.73 µg/ml exhibited significant activity than standard drug Aspirin (IC50, 107.75 µg/ml). The compound 12a out of the twelve newly prepared quinoline heterocycles displayed superior antileukemic activity and was comparable with the standard drug against human monocytic leukemia cell lines (THP-1). Representing the two different quinolinyl-pyrazole/thiophene analogues, compounds 11d, 11e, and 12a displayed the remarkable cytotoxicity against THP-1 cell lines with IC50 values 112.46, 105.42, and 98.88 µg/ml respectively.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
