Abstract
Newer Pyrrole-Chromones Chalcones (I–VII) were prepared by a simple method. among the series of compounds, compound −1 which was synthesized with 30 % of NaOH solution, at temperature of 60–65 °C with twelve hours of reaction time resulted in good yield. While, the other compounds under same and varying conditions resulted in less yield. Existing reports showed that this group of compounds showed insulysin inhibition, interleukin antagonist, and membrane integrity agonist activities. The proteins EGFR and HER-2 which are over expressed in breast cancer, in In silico studies with the titled compounds showed strong binding affinity when compared to the standard drug tamoxifen, which clearly indicate that these compounds possess anti-breast cancer activity. Hence, it can be concluded that these compounds has the potential to develop as anti-breast cancer drugs.
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