Abstract
Eight novel pyridyl–oxazole carboxamides were evaluated against fungi and displayed good fungicidal activities against Botrytis cinereal and Rhizoctonia solani. Preliminary bioassay results indicated that at 100 mg/L, compounds 6a–6e, 6g and 6h exhibited 100% fungicidal activities against Botrytis cinerea, and the compound 6b to Rhizoctonia solani at 100%. Then, the zebrafish embryo acute toxicity test was performed to assess the toxicity of 6b and 6c. A series of malformations appeared, when the zebrafish embryos were exposed to 6b and 6c, such as delayed yolk sac resorption, significant shortening of body length, pericardial edema, bending spine, lack of melanin, heart hemorrhage, head hemorrhage, delayed swim sac development, yolk malformation and head malformation. In addition, the acute toxicity of 6b to zebrafish embryo is 4.878 mg/L, and 6c is 6.257 mg/L.
Highlights
In the early 20th century, pesticide, as a helpful partner for agriculture, came into our lives
Lots of people realized the fact that every coin has two sides: the effective pesticides may be hazardous to human health and the environment
The mushrooming human population has come with a booming economy, followed by the unexpected impact from the accumulation of environmental pollution caused by abusing pesticides
Summary
In the early 20th century, pesticide, as a helpful partner for agriculture, came into our lives. Amide compounds with ideal biological activity and metabolic properties were widely used in insecticide and fungicide [5,6]. Since the 20th century, many highly active amide-containing fungicidal drugs containing. Amide compounds with ideal biological activity and metabolic properties pesticides. Since the 20th century, many highly active amide-containing fungicompoundsstructures [7,8,9,10,11]. Same time, pyridine derivalogical activity.isThus, the compound is widely used inAt thethe field of pesticides. The derivatives compound is is widely(Figure used in in2)the the field of pesticides. Oxazole derivatives [22,23,24,25,26,27] (Figure 2) have important nitrogen-containing heterocyclic compounds. Attracted attention as important nitrogen-containing heterocyclic compounds.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
