Abstract
Background: We previously designed an electrospinning chitosan (CS) nanofiber-based carrier, using polyvinyl alcohol (PVA) as an adjuvant to deliver doxorubicin (DOX) and MoS2 nanosheets for postoperative tumor re-occurrence inhibition. However, owing to that the nanofibrous mat is un-injectable, this composite nanofiber is far from being clinically applicable. Materials and Methods: Via modulating the electrospray parameters, polyvinyl alcohol (PVA) beads string doped with DOX and MoS2 (PVA/MoS2/DOX microspheres) were prepared, which were further crosslinked with glutaraldehyde to obtain the water-stability. Results: Under the 808-nm laser irradiation, MoS2 nanosheets rendered the prepared PVA/MoS2/DOX microspheres an excellent light-to-heat conversion performance with η of 23.2%. Besides, the heat generated by near-infrared laser irradiation can improve the effect of chemotherapy by promoting the release rate of DOX. HT29 cell and tumor-bearing nude mice were used to systematically study the combined tumor treatment efficiency of composite nanospheres. Conclusion: PVA/MoS2/DOX nanospheres have excellent photothermal effect and chemotherapy effect, which can completely suppress the tumor recurrence. Therefore, the PVA/MoS2/DOX nanospheres are anticipated to find potential applications in the treatment of local colorectal cancer.
Highlights
MoS2 nanosheets that were prepared according to our previous research [18] and DOX (Beijing Huafeng Pharmaceutical Co., Ltd., Beijing, China) were mixed with the polyvinyl alcohol (PVA) solution for electrospinning under ambient
MoS2 nanosheets that were prepared according to our previous research [18] and DOX (Beijing Huafeng Pharmaceutical Co., Ltd., Beijing, China) were mixed with the PVA solution for electrospinning under ambient conditions to prepare PVA/MoS2 and PVA/MoS2 /DOX microspheres
The proportion of high-viscosity and lowviscosity PVA determines whether the resultant product PVA can form a bead-like structure during the electrospinning
Summary
The encouraging long-term therapy outcome of CRC, oncologists are facing new challenges for current treatments. We previously designed an electrospinning chitosan (CS) nanofiber-based carrier, using polyvinyl alcohol (PVA) as an adjuvant to deliver doxorubicin (DOX) and MoS2 nanosheets for postoperative tumor re-occurrence inhibition. Results: Under the 808-nm laser irradiation, MoS2 nanosheets rendered the prepared PVA/MoS2 /DOX microspheres an excellent light-to-heat conversion performance with η of 23.2%. The heat generated by near-infrared laser irradiation can improve the effect of chemotherapy by promoting the release rate of DOX. HT29 cell and tumor-bearing nude mice were used to systematically study the combined tumor treatment efficiency of composite nanospheres. Conclusion: PVA/MoS2 /DOX nanospheres have excellent photothermal effect and chemotherapy effect, which can completely suppress the tumor recurrence
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