Abstract
Herein, a novel on-off-on fluorescent chemosensor for copper (II) ion (Cu2+), iron (III) ion (Fe3+) and cysteine is developed simply by the nano-precipitation method. The prepared organic dots with AIEgens (AIE dots) are advantageous over other metal ions in detecting Cu2+, Fe3+ with high selectivity and sensitivity by forming agglomerations (on-off). The agglomerations formed by AIE dots and Cu2+ redistributed and the fluorescence was obviously recovered in the presence of cysteine (off-on). This sensor has a wide linear range for Cu2+, Fe3+ and cysteine. The fluorescent detection limits of AIE dots are calculated to be 107 nM for Cu2+, 120 nM for Fe3+ and 78 nM for cysteine, respectively. These results indicate that the AIE dots can be used as a potential probe for Cu2+, Fe3+ and cysteine detection.
Highlights
Different metal ions play very important roles in all organism [1]
Cysteine is an essential amino acid, which plays a vital role in organisms in protein synthesis, and metabolism [15,16,17]
Deionized water with a resistivity of 18.2 MΩ·cm was used from a Milli-Q water purification system (Millipore Corp., Billerica, MA, USA)
Summary
Different metal ions play very important roles in all organism [1]. Excess Cu2+ and Fe3+ lead to numerous diseases, such as liver damage, anemia and Alzheimer’s disease [6,7,8]. Cysteine is an essential amino acid, which plays a vital role in organisms in protein synthesis, and metabolism [15,16,17]. Dysregulation of cysteine in vivo can cause many diseases, such as liver damage, slowed growth, osteoporosis cardiovascular disease [18,19,20]. Quantitative analysis of cysteine is of great importance for the development of biomedicine [21,22]
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