Abstract
The aim of this review was discussion on the new protein and lipid factors and their role in the pathomechanism of preeclampsia. Sphingolipids discussed in the review: Sph (sphingosine), S1P (sphingosine- 1-phosphate), C20-Cer (ceramides containing arachidic acid), C18-Cer (ceramides containing stearic acid), C16-Cer (ceramides containing palmitic acid), C18: 1-Cer (ceramides containing oleic acid), C22-Cer (ceramide containing behenic acid) and C24: 1-Cer (ceramides containing nervonic acid). Angiogenic factors discussed in the review: Hb-EGF (heparin-binding EGF-like growth factor), HGF (hepatocyte growth factor), LIF (leukaemia inhibitory factor), leptin, PDGF-BB (platelet-derived growth factor BB) and follistatin. Based on literature findings, it seems that protein and lipid factors may play an important role in the pathogenesis of preeclampsia, and there are many proteins and lipids that have not been studied in plasma of women with PE to date. We showed a few new pathways in pathomechanism of preeclampsia.
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