Abstract
AbstractTwo new potentiometric sensors were created for the quantification of bisoprolol fumarate and alverine citrate in bulk pharmaceutical dosage forms and human serum. Bisoprolol and alverine sensors were manufactured by combining potassium tetrakis (p-chlorophenyl) borate ion pairs to serve as electroactive substances, plasticized poly (vinyl chloride) matrix membranes, ando-nitrophenyl octyl ether. They demonstrated high responses over the concentration ranges of 1.0×10−6to 1.0×10−2mol L−1bisoprolol and alverine with close to Nernstian cationic slopes of 52 and 56 mV decade−1, respectively. The detection limits for bisoprolol and alverine were 2.6×10−6and 1.75×10−6mol L−1, respectively. For both medications, the response time was instantaneous (2.0 s). The working pH ranges for bisoprolol and alverine were 4.50–8.50 and 2.00–8.80, respectively. For both sensors, the life cycle was long (3 months). The sensors were used in pharmaceutical dosage types for the assay of bisoprolol and alverine, recording average recoveries of 99.40% and 99.98% respectively and were also successfully used for estimating the two drugs in human serum with an average recovery of 99.60% for both drugs. For all multiple staged interfering materials, the reported latest potentiometric sensor methods displayed high selectivity. The current sensor obtained a high percentage recovery and an excellent relative standard deviation compared with those obtained from previously published methods.
Highlights
Potentiometry is an electrochemical method widely studied by researchers due to its many advantages
In potentiometric sensor methods (potassium tetrakis (p-chlorophenyl) borate (KTp-ClPB) as a newer ion exchange used for the determination of bisoprolol fumarate or alverine citrate
Referring to IUPAC [36], the electrochemical potentiometric sensor was measured, showing that it exhibited near-Nernstian responses over the concentration ranges of 1.0×10-6-1.0×10-2 mol L-1 of drugs with 52 and 56 mV/decade cationic slopes for Bisoprolol fumarate (BIS) and Alverine citrate (ALV), respectively (Figure 2, Table 1)
Summary
Potentiometry is an electrochemical method widely studied by researchers due to its many advantages. From a medical point of view, clinical drug research and the determination of drugs in biological samples are extremely significant. Such experiments are performed using various analytical instruments, including electrochemical sensors. With regards to many parameters, potentiometric sensors can out-perform other instruments and are commonly used in research. The use of potentiometric sensors to recognize drug molecules in body fluids has shown promising results in the literature. We apply potentiometry-based sensors to biological blood serum samples for the determination of drugs and document their performance characteristics [1,2,3,4,5]
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