Abstract
This study is aimed to evaluate the biocompatibility and bioactivity of some new porous forsterite ceramics (FCs) produced from high-purity nano forsterite powder, synthesized by an original sol-gel method, which was subjected to pressing into pellets, by using a poly vinyl alcohol solution as a binding component. Then, the raw pellets were sintered at 1200 �C, 1300 �C, 1400 �C and 1450 �C. The obtained four forsterite ceramics, FC-1200, FC-1300, FC-1400 and FC-1450, were fully characterized by density, porosity and shrinkage measurements. The forsterite ceramics exhibited excellent biocompatibility determined by an in vitro cell viability assay, such as MTT test. Furthermore, the in vitro bioactivity test was performed by immersing the forsterite ceramics into simulated body fluid (SBF) and examining the hydroxyapatite (HAP) formation on forsterite ceramics, as evidenced by XRD, FTIR, SEM with EDX. Moreover, the relationship between porous structure and bioactivity of forsterite ceramics in SBF as well as the performance of FC in a cell culture was evaluated. The findings strongly recommend these forsterite ceramics for biomedical applications, as potential bone substitutes.
Highlights
This study is aimed to evaluate the biocompatibility and bioactivity of some new porous forsterite ceramics (FCs) produced from high-purity nano forsterite powder, synthesized by an original sol-gel method, which was subjected to pressing into pellets, by using a poly vinyl alcohol solution as a binding component
These findings indicate that both nano forsterite powder and forsterite ceramics can lead, in vivo, to a proper effect on bone calcification [24] and bone repair [27,28]. and they can be a potential biomaterial for tissue engineering
Four novel porous forsterite ceramics were synthesized from nanostructured forsterite powders prepared by an original sol - gel method, by using the sintering process at 1200, 1300, 1400 and 1450 oC
Summary
This study is aimed to evaluate the biocompatibility and bioactivity of some new porous forsterite ceramics (FCs) produced from high-purity nano forsterite powder, synthesized by an original sol-gel method, which was subjected to pressing into pellets, by using a poly vinyl alcohol solution as a binding component. More scientific research is needed to assess the usage of bioactive forsterite ceramics for load bearing bone and denture prosthesis In this respect, it is already recognised that the in vitro and in vivo performance of nanostructured forsterite ceramics depends on various factors, like the stability of forsterite structure, which is influenced by both preparation conditions of nano forsterite powder and fabrication method of forsterite ceramics [8,9,10,11,12]. Forsterite ceramics can even provide promising alternatives for the replacement of a bone part, [22] due to its expected high bioactivity, which is inherited from forsterite nanoparticles [14] It may improve cells attachment and proliferation and, it might generally reduce the necessary time for osseointegration of implanted materials, as has recently been demonstrated [23]. It is recognized that when released into a biological environment, for instance in simulated body fluid, SBF, Si and Mg, are replaced by Ca and P ions [26] leading to the formation of a hydroxyapatite (HAP) layer on the surface of forsterite particles [14]
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