Abstract
Chemical investigation of the dichloromethane extract of the Red Sea marine sponge Lamellodysidea herbacea led to the isolation of four novel polyhydroxysteroids: cholesta-8-en-3β,5α,6α,25-tetrol ( 1), cholesta-8(14)-en-3β,5α,6α,25-tetrol ( 2), cholesta-8,24-dien-3β,5α,6α-triol ( 3), and cholesta-8(14),24-dien-3β,5α,6α-triol ( 4). Their structures were identified through 1D and 2D NMR studies. Relative stereochemistries were established by analysis of chemical shifts, coupling constants, and NOESY correlations. Compounds 3– 4 showed antifungal activity against Candida tropicalis, with an inhibition diameter of 13 and 11 mm at 10 μg/disc, respectively.
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