Abstract
Phytochemical investigation of Vernonia urticifolia resulted in isolation of urticifolene, a new polyene metabolite together with lutein and sitosterol, which were fully characterized using NMR spectroscopy with the application of correlation spectroscopy (COSY), Nuclear overhauser enhancement spectroscopy (NOESY), heteronuclear multiple bond spectroscopy (HMBC) and heteronuclear single quantum coherence (HSQC). The biological assay determination showed that Lutein inhibited the growth of Enterococcus faecium at low concentration (MIC) of 8 μgmL-1, while urticifolene inhibited the growth ofEnterococcus faecium and Pseudomonas aeruginosa at low concentration (MIC) of 16 and 32 μgmL-1, respectively. In contrast to the related polyenes, nystatin and amphotericin B, which exhibit no antibacterial activity, urticifolene exhibited inhibitory property against all the bacteria investigated. Key words: Urticifolene, lutein, antibacterial activity, Vernonia urticifolia, Asteraceae.
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