Abstract
In this work, we designed replica particles based on poly(L-lysine) (PLL) polymers crosslinked via a homobifunctional linker to support coadsorption of a plasmid DNA and a peptide hormone for concurrent transfection and induction of a cellular function. PLL replica particles (PLLRP) were prepared. Based on this PLLRP gene delivery system, we simultaneously evaluated the melanin stimulation and gene expression by fluorescence microscopy. Our data suggest that the PLLRP is a promising vector for gene therapy and hormone stimulation.
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