Novel physiologic chemical method of labeling protein substances with the radionuclides of indium

Abstract

A novel chemical method of labeling plasma proteins, compounds and substances containing proteins with the radionuclides of indium at physiologic pH 6-8 condition producing an efficiently labeled radioactive tracer material suitable for biomedical applications. These radiolabeled protein substances are not denatured by the labeling process but retain their native physiobiological properties. This novel labeling technique provides a simple and rapid means of labeling plasma proteins such as human serum albumin, transferrin, lactoferrin, fibrinogen, and immunoglobulin or antibodies with 111 In or 113m In for scintigraphic imaging which may allow visualization of thrombi, emboli, myocardial infarcts, infectious lesions, tumors or any vascular abnormalities in the body.