Abstract
Novel thermal nanoparticles [hollow mesoporous silica nanospheres (HMSNs)–poly (N-isopropyl acrylamide-acrylic acid) PNIPAM-AA] were developed with Ag nanoparticles (AgNps) as the core, mesoporous silica nanoparticles as the layer, and thermally responsive polymers PNIPAM-AA as the shell. The AgNps had good photothermal effects, PNIPAM-AA was responsive to temperature, the combination of AgNps and PNIPAM-AA could be used as a photothermal-responsive switch for drug release, and HMSNs greatly increased the drug loading of the carrier. The samples were characterized by means of scanning electron microscopy, transmission electron microscopy, N2 adsorption–desorption, thermogravimetric analysis, Fourier transform infrared spectroscopy, and UV–Vis absorption spectra. The results showed that Ag@HMSN nanoparticles possessed a uniform diameter (330 nm), high specific surface area (822.45 m2/g), and mesoporous pore size (2.75 nm). Using ibuprofen (IBU) as a model drug, the release process was monitored under in vitro conditions to investigate its release characteristics at different temperatures. The results showed that the nanoparticles had a significant regulatory effect on IBU release.
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