Abstract
Novel Photothermal Aptamer-based Sensing System for Highly Ultrasensitive Detection of Ochratoxin A
Highlights
Toxic fungi produce toxic secondary metabolites during their harvest, storage, and processing
We developed a simple photothermal sensing system based on the high selectivity of an aptamer and the photothermal effect of the TMB–H2O2 colorimetric system catalyzed by Fe3O4 NPs
In the presence of ochratoxin A (OTA), the Fe3O4 NP–aptamer preferentially switches its configuration to combine with the OTA target, resulting in the aptamer being released from the double helix structure to form a specific structure with OTA [Fig. 1(b)]
Summary
Toxic fungi produce toxic secondary metabolites during their harvest, storage, and processing The ingestion of these metabolites is a potential threat to humans and animals.(1) Among these metabolites, ochratoxin A (OTA) is one of the most common and harmful substances,(2) and is nephrotoxic, immunosuppressive, and carcinogenic.(3) a sensitive and efficient analytical method is required for its determination. The determination of various mycotoxins has been greatly improved in terms of the detection limit, accuracy, ease of operation, and so forth.(11) biosensors are still far from reaching practical application and considerable further research is required. To develop a sensing system with high sensitivity, wide linear range, long service life, and ease of use, researchers have recently focused on the selection of sensor receptors, the signal transmission strategy, the use of new materials, the signal generation mechanism, and so forth
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