Abstract
Block copolymers, composed of MPEG, PCLA and PAE, were synthesized through a combination of ring opening reaction and Michael reaction. Their aqueous solutions show a sensitive sol-gel transition by pH and temperature within a small pH range. The sol-gel phase diagrams of the block copolymer solutions were controlled deliberately by altering either the ratio of hydrophobic to hydrophilic blocks within the block copolymer or the PEG length. The aqueous block copolymer solution composed of MPEG=5,000, PEG/PCL ratio=1/0.3 and PAE=847 had a gel region including thein vivo conditions (37°C, pH 7.4). This polymer solution could be formulated with various drugs at pH 5∼6 buffer solution for the injection to the human body. This could be one of the candidate of the injectable hydrogel for the sustained release of drug.
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