Novel patterns for the growing main bronchi in the human fetus: an anatomical, digital and statistical study

Abstract

PurposeIntensive progress in prenatal medicine results in performing airway management in the fetus affected by life-threatening congenital malformations. This study aimed to examine age-specific reference intervals and growth dynamics for length, proximal and distal external transverse diameters, and projection surface areas of the two main bronchi at varying gestational ages, including their relative growth in length and projection surface area.Materials and methodsUsing anatomical dissection, digital image analysis and statistics, length, proximal and distal external transverse diameters, and projection surface areas of the right and left main bronchi were examined in 73 human fetuses (39 males, 34 females) aged 14–25 weeks, derived from spontaneous abortions and stillbirths.ResultsStatistical analysis showed no sex differences. Between the 14 and 25th week of gestation, the lengths of the right and left main bronchi increased from 1.43 ± 0.18 to 3.18 ± 0.39 mm, and from 2.97 ± 0.16 to 7.58 ± 1.95 mm, in accordance with the functions: y = - 4.850 + 2.452 x ; text{ln}left( {text{Age}} right) pm 0.400;{text{and}};y = - 15.005 + 7.093x ; text{ln} left( {text{Age}} right) pm 0.579 , respectively. The proximal external transverse diameters of the right and left main bronchi varied from 2.13 ± 0.41 to 4.24 ± 0.20 mm, and from 1.84 ± 0.06 to 3.67 ± 0.66 mm, following the logarithmic models: y = - 8.666 + 4.018x ; text{ln}{rm (Age)} pm 0.367;{text{and}};y = - 6.938 + 3.305x{text{ ln(Age) }} pm 0.323 , respectively. The distal external transverse diameter rose from 2.09 ± 0.47 to 4.24 ± 0.20 mm, as y = - 8.723 + 4.021x{text{ ln(Age)}} pm 0.392 for the right main bronchus, and from 1.85 ± 0.04 to 3.67 ± 0.66 mm, like y = - 6.924 + 3.280x{text{ ln(Age)}} pm 0.348 for the left one. On either side, there were no statistically significant differences between values of the proximal and distal transverse diameters of the main bronchus. The projection surface areas of the right and left main bronchi ranged from 2.95 ± 0.19 to 13.34 ± 2.12 mm2, and from 5.57 ± 0.21 to 28.52 ± 5.24 mm2, as y = - 10.212 + 0.943x{text{ Age}} pm 1.739 and y = - 19.119 + 1.875x{text{ Age}} pm 3.054 . The two main bronchi revealed a proportionate increase in both length and projection surface area, since the right-to-left bronchial length ratio and the right-to-left bronchial projection surface area ratio were stable, 0.41 ± 0.07 and 0.47 ± 0.08, respectively, throughout the analyzed period.ConclusionsThe main bronchi show no sex differences. The right and left main bronchi grow logarithmically in length and external transverse diameter, and linearly in projection surface area. The right and left main bronchi evolve proportionately, with the right-to-left bronchial ratios of 0.41 ± 0.07 for length, and 0.47 ± 0.08 for projection surface area.