Novel Paravascular Lesions with Abnormal Autofluorescence in Pathologic Myopia

Abstract

Novel paravascular lesions with abnormal autofluorescence (AF) were found in eyes with pathologic myopia. Most lesions were uniform hypo-AF, followed by hyper-AF, and granular hypo-AF. Optical coherence tomography showed retinal thinning with or without defects of the retinal pigment epithelium. Pathologic myopia (PM) is characterized by an increase in the axial length of the eye and formation of posterior staphylomas. Much attention has been paid to the macular lesions in the clinical management of patients with PM. However, recent studies have shown that wider areas of the fundus can be affected such as radial tracts that emanate from the upper staphyloma edges and peripheral avascular zones. These findings suggested that PM may not simply be a macular disorder but a disorder with various pathologies in wide areas of the fundus including the far periphery.