Abstract
A novel one-pot neutral synthesis using bioinspired polymers to fabricate thiol-nanoparticles ispresented. The thiol-particles may be directly tethered to metal surfaces such asgold, allowing the production of self-assembled nanostructured biocatalytic orbiosensor surfaces. This one-pot method has also been used to entrap enzymeswithin the thiol-nanoparticles; it is apparent that once enzyme entrapment iscarried out a bimodal distribution of particles is formed, with particles of onemode being very similar in size to thiol-nanoparticles without enzyme entrapped,and particles of the other mode being much larger in size. To this end, effortshave been made to separate the two modes of particles for the sample containingenzyme and it has been observed that the larger mode thiol-nanoparticles do indeedcontain significant amounts of enzyme in comparison to the smaller mode ones.As the enzyme-containing thiol-nanoparticles can now be isolated, this meansthat there are many future possibilities for the use of thiol-particles containingenzyme, as they may be used in a wide range of processes and devices which requirecatalytic functionalized surfaces, such as biosensors and biocatalytic reactors.
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