Abstract
As potential lead structures for a new class of glycosidase inhibitors the novel O-glycosyl amino acid mimetics 3′- O-[2,6-anhydro- d- glycero- l-gluco-heptitol-1-yl]- l-serine 3 and- l-threonine 4 were synthesized, employing regio- and stereoselective aziridine ring opening methodology. They proved to be stable in the presence of glycosidases and showed competitive inhibition of α-galactosidase from Aspergillus niger.
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