Abstract
Nowadays, N-heterocyclic carbene-based silver-complexes Ag(I) have been widely used as an organometallic drug candidate in medicinal and pharmaceutical chemistry researches due to their low toxicity. Due to the success of Ag(I) complexes in biological applications, interest in the synthesis and applications of such compounds is increasing rapidly. Therefore, in this study, a series of unsymmetrical N,N-disubstituted benzimidazolium salts were synthesized as N-heterocyclic carbene (NHC) (2a-2j). The interaction of these benzimidazolium salts having their two nitrogen atoms substituted by bulky groups with Ag2O in DMF has been carried out to afford Ag(I) complexes and characterized by 1H NMR, 13C NMR, FT-IR and elemental analyses. The antimicrobial activity of Ag(I) complexes was tested against some standard culture collections of Gram-negative, Gram-positive bacterial strains and Fungal strains, which are the most frequently isolated among the society and hospital-acquired infectious microorganisms as potential metallopharmaceutical agents. The Ag-NHC complexes showed effective antimicrobial activity against microorganisms with MIC values between 0.0024 and 1.25 mg/ml. Moreover, these Ag-NHC complexes exhibited significant antioxidant activities. In addition, of benzimidazoles salts 2,4 and Ag(I) complexes 3,5 were screened for their antitumor activity. The highest antitumor activity was observed for 3e and 3d Complexes.
Highlights
N-Heterocyclic carbenes (NHCs) are nitrogen-based heterocyclic compounds containing a divalent carbon atom
We concluded that the presence of electron-donating and bulky substituents attached to the nitrogen of the carbene ligand increases the antimicrobial activity of the silver complexes
We report the synthesis of novel NHC salts and their Ag(I) complexes and investigate their antimicrobial, antioxidant and cytotoxic activities
Summary
N-Heterocyclic carbenes (NHCs) are nitrogen-based heterocyclic compounds containing a divalent carbon atom. Heterocyclic molecules are an important family of organic chemistry with a wide range of applications [35] This family is generally known for its agrochemical and veterinary applications, it is used as a corrosion inhibitor, sanitizer, and dyestuff [36]. We concluded that the presence of electron-donating and bulky substituents attached to the nitrogen of the carbene ligand increases the antimicrobial activity of the silver complexes. These exciting results have led us to further investigate the antimicrobial properties of silver-NHCs. These exciting results have led us to further investigate the antimicrobial properties of silver-NHCs In this regard, we report the synthesis of novel NHC salts and their Ag(I) complexes and investigate their antimicrobial, antioxidant and cytotoxic activities. All salts and complex structures were characterized by elemental analysis, Fourier transforms infrared (FTIR), 1H and 13C nuclear magnetic resonance (NMR) spectroscopies
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
