Abstract
Quantification of bioactive molecules through voltammetry techniques is significant over the past decades, due to its adaptability and precision of assessment at the trace level. The present study involves a sensitive voltammetric process for the detection of nimesulide (NIM) was developed at nanoclay (NC) blended carbon paste electrode (CPE) applying voltammetric techniques such as cyclic voltammetry (CV) and square wave voltammetry (SWV) in a media of pH 7.0 phosphate buffer (PB) solution. The proposed nanosensor increased peak current by a less negative shift in the potential due to electro-catalytic properties of nanoclay particles. The persuade of physicochemical constraint on the voltammetric behavior of NIM were studied. Based on the obtained results, number of protons and electrons participated in the electrooxidation reaction, heterogeneous rate constant value, detection and quantification limits were also calculated. The proposed electrode showed lower detection limit value of 1.01 nM and hence, can be used to determine NIM in tablet and urine samples with good recovery values.
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