Novel n-octadecylcarboxamide CoPc: amperometric detections for bioanalytes using modified GCE

Abstract

Here, we are reporting cobalt(II) phthalocyanine (CoPc) containing the active catalyst for the electrochemical investigations of bioanalytes. The synthesized tetra-n-octadecylcarboxamide cobalt(II) phthalocyanine was characterized by FT-IR, UV, TGA, mass and powder XRD analysis. In the present work, the synthesized complex was characterized by cyclic voltammetry and shows the redox behaviour corresponding to central metal (Co+II/Co+I) of the complex. Three biomolecules are well separated by their oxidation peaks in simultaneous detections of AA, DA and UA at 170, 350 and 550 mV with increasing high positive peak current. The low detection limit of AA, DA and UA was 40, 30 and 30 µmol by CV methods. The modified tetra substituted CoODAPc/GCE exhibits an excellent electrocatalytic activity, stability, high sensitivity, good linearity and selectivity without losing its catalytic activity and proves to be a versatile chemical sensor for commercial pharmaceutical samples, vitamin C tablets and dopamine injections.