Abstract
Pasteurella multocida causes fowl cholera, a highly contagious poultry disease of global concern, causing significant ecological and economic challenges to the poultry industry each year. This study evaluated the effects of novel multi-strain probiotics consisting of Lactobacillus plantarum, L. fermentum, Pediococcus acidilactici, Enterococcus faecium and Saccharomyces cerevisiae on growth performance, intestinal microbiota, haemato-biochemical parameters and anti-inflammatory properties on broilers experimentally challenged with P. multocida. A total of 120 birds were fed with a basal diet supplemented with probiotics (108 CFU/kg) and then orally challenged with 108 CFU/mL of P. multocida. Probiotics supplementation significantly (P < 0.05) improved growth performance and feed efficiency as well as reducing (P < 0.05) the population of intestinal P. multocida, enterobacteria, and mortality. Haemato-biochemical parameters including total cholesterol, white blood cells (WBC), proteins, glucose, packed cell volume (PCV) and lymphocytes improved (P < 0.05) among probiotic fed birds when compared with the controls. Transcriptional profiles of anti-inflammatory genes including hypoxia inducible factor 1 alpha (HIF1A), tumor necrosis factor- (TNF) stimulated gene-6 (TSG-6) and prostaglandin E receptor 2 (PTGER2) in the intestinal mucosa were upregulated (P < 0.05) in probiotics fed birds. The dietary inclusion of the novel multi-strain probiotics improves growth performance, feed efficiency and intestinal health while attenuating inflammatory reaction, clinical signs and mortality associated with P. multocida infection in broilers.
Highlights
Pasteurella multocida causes fowl cholera, a highly contagious poultry disease of global concern, causing significant ecological and economic challenges to the poultry industry each year
This study aimed to investigate the effect of dietary supplementation with novel multi-strain probiotic on the growth performance, intestinal microflora, haemato-biochemical parameters and anti-inflammatory properties on P. multocida infection in broilers
From the beginning of this experimental trial, i.e., days 1 to 14, no statistically significant (P > 0.05) differences were recorded in the body weight (BW), body weight gain (BWG), feed intake (FI) and feed conversion ratio (FCR) among all the treatments
Summary
Pasteurella multocida causes fowl cholera, a highly contagious poultry disease of global concern, causing significant ecological and economic challenges to the poultry industry each year. Pasteurella multocida is a Gram-negative coccobacillus and readily transmitted bacterium which causes fowl or avian cholera, an acute and fatal septicemic infection affecting wide range of both wild and domestic bird species[1,2] In poultry, it causes significant economic loss on back-yard and large-scale commercial poultry production globally[3,4]. The regular inclusion of probiotics in poultry diets may both minimize the risk of infections with pathogens such as P. multocida, E. coli, Campylobacter spp., Listeria monocytogenes and Salmonella as well as improving growth performance in b irds[14] This would significantly decrease the risks associated with poultry and poultry product contamination with animal pathogens of public health concern, reducing human spread as well as safeguarding the environment
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