Abstract
Multicomponent reactions of 2,2-dimethylpenta-3,4-dienal oxime with aldehydes and primary alcohols were studied and the optimum conditions for preparing a new family of 2,5-substituted five-membered cyclic nitrones were identified. This reaction offers direct access to the target structures in a single synthetic step. The scope and limitations of the reaction were evaluated, and all products were isolated and fully characterized.
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