Abstract
Measuring the electrical potential of a neuron cell currently requires direct contact with the cell surface. This method requires invasive probing and is limited by the deflection of electricity from baseline. From a clinical perspective, the electrical potential of the brain's surface can only be measured to a depth of one centimeter using an electroencephalogram (EEG), however, it cannot measure much deeper structures. In this trial, we attempt a novel method to remotely record the electromagnetic field (EMF) of action potential provoked from hippocampal neurons without contact.A bipolar stimulating electrode was placed in contact with the CA1 region of viable hippocampal slice from donor mice. The specimen was bathed in artifical cerebrospinal fluid (aCSF) to simulate in vivo conditions. This setup was then placed into a magnetic shielded tube. Very low-frequency EMF sensors were used to obtain recordings. The impedance of the aCSF and hippocampal slice were measured after each stimulation individually and in combination.An electromagnetic signal was detected in three out of four scenarios: (a) aCSF alone with electrical stimulus without a hippocampal slice, (b) Hippocampal slice in aCSF without electrical stimulus and, (c) Hippocampal slice in aCSF with an electric stimulus applied. Therefore, our trial suggests that EMFs from neuronal tissue can be recorded through non-invasive non-contact sensors.
Highlights
Neurological conditions, such as brain tumors, learning disorders, Alzheimer’s disease, Parkinson’s disease, and traumatic brain injury, have debilitating clinical presentations and profound social, financial, and emotional burden
A single bipolar electrode was placed in contact with the Cornu Ammonis 1 (CA1) region of the hippocampal slice, whose viability was verified under microscopic illumination prior to electrode placement
There was no electromagnetic signal obtained from the chamber with artifical cerebrospinal fluid (aCSF) alone and no stimulus (Table 1)
Summary
Neurological conditions, such as brain tumors, learning disorders, Alzheimer’s disease, Parkinson’s disease, and traumatic brain injury, have debilitating clinical presentations and profound social, financial, and emotional burden. Neurochemical alterations in these diseases may be measured through blood or cerebrospinal fluid testing.
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