Abstract

The level of sedation in ICU patients is difficult to assess, and relies on clinical assessments such as the Ramsay score. These tests discriminate deep sedation poorly. We evaluated a novel measure, EEG/EMG responsiveness, and compared it with Ramsay scores. EEG/EMG responsiveness was calculated by applying an algorithm that detects abrupt changes in the measured EEG signal indicative of a patient's arousal or activation. The results were compared with those obtained using the EEG entropy.

Highlights

  • Tight blood glucose (BG) control has been shown to videos of the alveolar dynamics

  • Computer-advised insulin infusion in postoperative cardiac surgery patients: a randomized prospective controlled multicenter trial quality the alveoli are observed at an open chest wall under a glass plate representing an artificial situation. To circumvent this restriction we developed a method of intravital endoscopy and tested it on an animal rat model

  • J Cordingley1, J Plank2, J Blaha3, M Wilinska4, L Chassin4, Methods In cooperation with Schoelly GmbH (Denzlingen, C Morgan1, S Squire1, M Haluzik3, J Kremen3, S Svacina3, Germany) we developed an endoscope with an outer tube diameter

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Summary

Introduction

Tight blood glucose (BG) control has been shown to videos of the alveolar dynamics. The thorax remains intact.decrease morbidity and mortality in critically ill patients [1] but is Results Figure 1 shows a tissue area after lavage of 0.8 mm difficult to achieve using standard insulin infusion protocols. Results Patient characteristics (mean ± SD): age 57.4 ± 15.4 years, 28 female, 52 male, APACHE II score 28.2 ± 6.6; number of organ failures 4.0 ± 1.12; preceding ICU period 8.5 ± 9.3 days; continuous sedation with midazolam 31.2 ± 34.2 mg/hour, fentanyl 0.12 ± 0.08 mg/hour, propofol 45.6 ± 105.2 mg/hour; sedation assessment according to RS 5.65 ± 0.63, CPS 5.15 ± 1.67, CKS 0.65 ± 0.69, CS 9.34 ± 2.13 und LSS 1.78 ± 1.69, RASS –4.50 ± 1.27, FiO2 0.52 ± 0.17, PEEP 8.2 ± 2.4 cmH2O, ventilatory frequency 20.5 ± 4.8/min, pressure control 16.8 ± 4.4 cmH2O, tidal volume 540 ± 115 ml, TVV 2525.6 ± 11,366 ml (minimum 1.52; maximum 91,586). We hypothesized that S100β levels correlate with this tumor’s preoperative characteristics and with perioperative neurological injury despite its supratentorial location and non-neural origin

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