Abstract
Lycorine, which is the most abundant alkaloid isolated from the Amaryllidaceae family of plants, reportedly exhibits promising anticancer activities. Herein, a series of novel lycorine derivatives were synthesized and evaluated for their in vitro inhibitory activities against seven different cancer cell lines, including A549, HCT116, SK-OV-3, NCI-H460, K562, MCF-7 and HL-60. The results indicated that compounds bearing diverse amine substituents at the C-2 position demonstrated good anticancer activities. The selectivity towards different cancer cell lines of the synthesized derivatives is discussed.
Highlights
Cancer is a proliferation disorder disease with apoptosis obstacles
In the present study we report the synthesis of some novel lycorine derivatives and the evaluation of their in vitro anticancer activities
Several derivatives were synthesized to investigate the influences of different substituents at the C-2 position
Summary
Cancer is a proliferation disorder disease with apoptosis obstacles. It strikes more than one-third of the World’s population and causes over 20% of all deaths [1]. The standard cancer treatment protocols include surgery, radiotherapy and chemotherapy. Chemotherapy is not effective in treating cancers associated with innate resistance to apoptosis and/or acquired resistance to drugs during treatment [2]. Discovery of novel effective anticancer medicines is of great importance. As a source of drugs, natural products play an important role in drug discovery.
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