Abstract
Aim: The aim of this study was to compare novel kidney injury biomarkers in sickle cell anemia (SCA) children with and without albuminuria orglomerular hyperfiltration. Materials & methods: A total of358 Brazilian children with SCA were studied. Fifteen kidney injury biomarkers in urine were measured. Albuminuria was defined as urine albumin/creatinine ratio >100mg/g. Glomerular hyperfiltration was defined as estimated glomerular filtration rate ≥140ml/min/1.73m2. Results: After adjustment for age, sex and modifying therapies in use, EGFand collagen IV urinary levels were associated with albuminuria. Renin and clusterin levels were associated withhyperfiltration. Conclusion: Levels of novel kidney injury biomarkers were associated with albuminuria andhyperfiltration in Brazilian children with SCA, suggesting concomitant structural and functional abnormalities.
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