Abstract
ObjectiveTo synthesize new congeners by incorporating isoniazid with 1,2,3,4-tetrahydropyrimidinones moieties in a single molecular frame work and to evaluate their antimicrobial and antimycobacterial activity. MethodsA new series of some novel isoniazid cyclocondensed 1,2,3,4-tetrahydropyrimidines was prepared by N′-acetoacetylisonicotinohydrazide with urea/thiourea and appropriate aldehyde in the presence of catalytic amount of laboratory made benzenesulphonic acid. Confirmation of the chemical structure of the synthesized compounds (4a-n) was substantiated by melting point, TLC, different spectral data IR, 1H-NMR, and Mass spectra were done. The synthesized compounds were evaluated for in vitro antimicrobial and antimycobacterial activity against Bacillus subtilis (B. subtilis), Escherichia coli (E. coli), Mycobacterium tuberculosis (M. tuberculosis) CIP and H37Rv strain. ResultsThe titled compounds exhibited weak, moderate, or high antimicrobial and antimycobacterial activity. Compounds 4l, 4m, and 4n, exhibited potential antimicrobial and antimycobacterial action, when compare with the current therapeutic agent of Norfloxacin and Rifampicin. ConclusionsCompound 4l, 4m, and 4n is arguably the most potent, our present study makes it an interesting compound when compared to the current therapeutic agents and are considered the candidates to investigate further for the same.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.