Abstract
Three new iridal metabolites, iridojaponal A (1), B (2) and iridojaponal C (3) were isolated from the whole plants of Iris japonica. Their structures were elucidated on the basis of comprehensive spectroscopic data and chemical evidence. Iridojaponal A (1) and B (2) are the first examples of degraded iridals containing only 16 carbons. A plausible biogenetic pathway of 1 and 2 was also proposed. The absolute configuration at C-22 of 3 was determined by CD analysis accordance with Snatzke’s method. Furthermore, In vitro bioactivity assays, compounds 1 and 2 exhibited moderate hepatoprotective activities against APAP-induced HepG2 cell damage at a concentration of 10μM.
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