Novel insights into circular RNA regulation in arsenic-exposure-induced lung cancer

Abstract

Lung cancer is the leading cause of cancer-related deaths worldwide and a major global public health problem that seriously threatens patients’ lives and health. Arsenic exposure is considered one of the main causes of lung cancer occurrence.1 However, the detailed mechanisms of arsenic exposure involved in the initiation and development of lung cancer are still largely unknown. A new class of regulatory noncoding RNAs called circular RNA (circRNA) exhibits distinct cellular roles in a variety of cancer types.