Novel individual metabolic profile characterizes the protein kinase B-alpha (pkbα−/−) in vivo model

Abstract

Context: Type 2 diabetes and associated co-morbidities run epidemic waves worldwide. Since pathophysiological constellations are individual and display a wide spread of dysmetabolic profiles personalized health care assessments start to emerge. Therefore, we established a specific in silico assessment tool targeting metabolic characterizations individually. Materials and methods: Values obtained from oral glucose and intraperitoneal insulin tolerance tests performed on pkbα−/− mice (KO) as well as age- and gender-matched controls (WT) were analysed using our established in silico model. Results: Generally, male pkbα−/− mice (KO) presented significantly increased insulin sensitivity at an age of 6 months compared with age-matched WTs (p = 0.036). Female KO and WT groups displayed improved glucose sensitivities compared with age-matched males (for WT p ≤ 0.011). Discussion and conclusion: Specific metabolic characterization should be assessed individually. Therefore, our in silico model enables novel insights inaugurating specific primary preventive strategies targeting individual metabolic profiling precisely.