Novel in-house knowledge-based automated planning system for lung cancer treated with intensity-modulated radiotherapy.

Abstract

The goal of this study was to propose aknowledge-based planning system which could automatically design plans for lung cancer patients treated with intensity-modulated radiotherapy (IMRT). From May 2018 to June 2020, 612 IMRT treatment plans of lung cancer patients were retrospectively selected to construct aplanning database. Knowledge-based planning (KBP) architecture named αDiar was proposed in this study. It consisted of two parts separated by afirewall. One was the in-hospital workstation, and the other was the search engine in the cloud. Based on our previous study, A‑Net in the in-hospital workstation was used to generate predicted virtual dose images. Asearch engine including athree-dimensional convolutional neural network (3D CNN) was constructed to derive the feature vectors of dose images. By comparing the similarity of the features between virtual dose images and the clinical dose images in the database, the most similar feature was found. The optimization parameters (OPs) of the treatment plan corresponding to the most similar feature were assigned to the new plan, and the design of anew treatment plan was automatically completed. After αDiar was developed, we performed two studies. The first retrospective study was conducted to validate whether this architecture was qualified for clinical practice and involved 96patients. The second comparative study was performed to investigate whether αDiar could assist dosimetrists in improving the quality of planning for the patients. Two dosimetrists were involved and designed plans for only one trial with and without αDiar; 26patients were involved in this study. The first study showed that about 54% (52/96) of the automatically generated plans would achieve the dosimetric constraints of the Radiation Therapy Oncology Group (RTOG) and about 93% (89/96) of the automatically generated plans would achieve the dosimetric constraints of the National Comprehensive Cancer Network (NCCN). The second study showed that the quality of treatment planning designed by junior dosimetrists was improved with the help of αDiar. Our results showed that αDiar was an effective tool to improve planning quality. Over half of the patients' plans could be designed automatically. For the remaining patients, although the automatically designed plans did not fully meet the clinical requirements, their quality was also better than that of manual plans.