Abstract
A series of amphiphilic hyperbranched poly (amine-ester)-poly (lactide-co-glycolide) (HPAE-co-PLGA) copolymers were synthesized by ring-opening polymerization of dl-lactide, glycolide and a fourth generation hyperbranched poly (amine-ester) (HPAE-OHs4) with Sn(Oct)2 as catalyst. The chemical structure of copolymers was characterized by Fourier transform infrared (FT-IR), nuclear magnetic resonance (1H-NMR, 13C-NMR), thermo gravimetric analysis apparatus (TGA), and different scanning calorimetry (DSC). Formation and characteristics of polymeric micelles of the amphiphilic copolymer were studied by environmental scanning electron microscopy (ESEM), fluorescence spectroscopy, and dynamic light scattering (DLS). In order to estimate the feasibility as novel drug carriers, a lipophilic model drug amphotericin B was incorporated into polymeric micelles and the drug release behavior was investigated. The micelle size and drug-loading content were found increased, and the drug-release rate decreased with the increase of molar ratio of dl-lactide/glycolide to HPAE.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
