Abstract
α,β-polyasparthydrazide (PAHy), a synthetic water-soluble biocompatible polymer, was chemically crosslinked with ethyleneglycol diglycidylether (EGDGE), in order to obtain water swellable microparticles. These were characterized by means of FT-IR spectrophotometry and by means of particle size distribution analysis. The mean pore size of the prepared gels at various crosslinking ratios and the fractal dimensions were determined by light scattering measurements. Swelling measurements gave evidence of the high affinity of PAHy-EGDGE microparticles towards aqueous media at different pH values. The physical state of the prepared networks was evaluated by means of X-rays diffractometry and thermal analysis. A peculiar effect of the degree of crosslinking on the glass transition temperature (Tg) value was shown. In vitro chemical and enzymatic stability studies suggested that the prepared samples do not undergo any degradation after treatment at pH 1, 7.4 and 10 as well as after incubation with enzymes such as pepsin and α-chymotrypsin.
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