Abstract
We report a novel human adenovirus D (HAdV-65) isolated from feces of 4 children in Bangladesh who had acute gastroenteritis. Corresponding genes of HAdV-65 were related to a hexon gene of HAdV-10, penton base genes of HAdV-37 and HAdV-58, and a fiber gene of HAdV-9. This novel virus may be a serious threat to public health.
Highlights
Human adenoviruses (HAdVs) are common pathogens that cause several diseases, such as pneumonia, acute gastroenteritis, and epidemic keratoconjunctivitis [1]
HAdV-65 was closely related to HAdV-37 and HAdV-58 in the hypervariable loop 1 and the Arg-Gly-Asp (RGD) loop of the penton base gene, respectively
SimPlot analysis showed no potential recombination in the hexon and fiber genes, and recombination between the hypervariable loop 1 and the RGD loop was predicted in the penton base gene
Summary
Human adenoviruses (HAdVs) are common pathogens that cause several diseases, such as pneumonia, acute gastroenteritis, and epidemic keratoconjunctivitis [1]. The complete genome of HAdV-65 was sequenced by using the primer walking method. Complete genome analysis showed that HAdV-65 was >5.0% distant from any other HAdV-D reference strains
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