Abstract
A novel H5N8 highly pathogenic avian influenza virus (HPAIV) was detected in a greater white-fronted goose in January 2020 in Brandenburg, Germany, and, in February 2020, in domestic chickens belonging to a smallholding in Baden-Wuerttemberg, Germany. Full-genome sequencing was conducted on the MinION platform, enabling further phylogenetic analyses. The virus of clade 2.3.4.4b holds six segments from a Eurasian/Asian/African HPAIV H5N8 reassortant and two segments from low pathogenic avian influenza H3N8 subtype viruses recently detected in wild birds in Central Russia. These new entries continue to show the reassortment potential of the clade 2.3.4.4 H5Nx viruses, underlining the necessity for full-genome sequencing and continuous surveillance.
Highlights
The severe European epizootic of highly pathogenic avian influenza viruses (HPAIV), peaking during the winter of 2016–2017, was dominated by viral swarm incursions and frequent reassortment events [1]
In comparison to the HPAIVs circulating during the 2016–2018 epizootic [2,5], the Ger-01-20 novel reassortant, Ger-01-20, revealing a distinct segment combination that differs from reassortants reassortant comprises of eight unique segments newly introduced to Germany (Figure 2 and Figure described in Germany 2016/2017 and similar reassortants circulating worldwide (Figure 2)
Harboring of segments with sequences related to those identified in an H3N8 LPAIV in wild waterbirds from Central Russia along with segments from the HPAIV
Summary
The severe European epizootic of highly pathogenic avian influenza viruses (HPAIV), peaking during the winter of 2016–2017, was dominated by viral swarm incursions and frequent reassortment events [1]. All belonged to group B of clade 2.3.4.4, six reassortants classifying into three subtypes were identified in Germany from November 2016 to August 2018 [2,3,4]. Phylogenetic analyses of the H5N8 subtypes pointed to individual incursion events, as similar H5N8 HPAIV reassortants were found prior to the German epizootic in migratory wild water bird molting and resting areas in the regions surrounding Tartastan, Kurgan, and Lake Chany, Russian Federation [2,5]. Since January 2020, a clade 2.3.4.4b virus has been detected in Germany in the form of a novel H5N8 reassortant, Ger-01-20
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