Abstract
A serie sof analogues of LY289612 were prepared as HIV-1 protease inhibitors and evaluated in vitro for their enzyme inhibitory and antiviral activities. Compound 1, a potent HIV-1 protease inhibitor, and its analogues were synthesized from key intermediate 9, which was prepared by alkylation of mercaptan 4 with α-bromo ketone 7 followed by stereroselective reduction of the ketone intermediate 8.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
