Abstract
Near full-length genomes of 4 unclassified HIV-1 variants infecting patients enrolled in an antenatal cohort in Canada were obtained by sequencing. All 4 variants showed original recombination profiles, including A1/A2/J, A1/D, and A1/G/J/CRF11_cpx structures. Identification of these variants highlights the growing prevalence of unique recombinant forms of HIV-1 in North America.
Highlights
Near full-length genomes of 4 unclassified HIV-1 variants infecting patients enrolled in an antenatal cohort in Canada were obtained by sequencing
Multiple circulating recombinant forms (CRFs) and unique recombinant forms (URFs) contain segments related to subtypes A and J, sequences from patients TV721 and TV749 are 2 of only 3 full-length HIV-1 genomes reported that exclusively comprise sequences related to subtypes A and J (12)
The HIV-1 isolates that infected patients TV721, TV725, TV749, and TV919 had more recombination breakpoints and unclassified regions than most CRFs and URFs, highlighting their unique recombination profiles and structural complexity
Summary
Near full-length genomes of 4 unclassified HIV-1 variants infecting patients enrolled in an antenatal cohort in Canada were obtained by sequencing. Bootscan analysis showed complex recombinant structures for all 4 full-length or near full-length genomes (Figure). Genetic organization and recombination breakpoints in HIV-1 genomic sequences isolated from patients TV721 (A), TV725 (B), TV749 (C), and TV919 (D).
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