Abstract
A novel fluorimetric sensor was synthesized by coating molecularly imprinted polymers (MP) layer on carbon nanoparticles (CNPs) that prepared from gum tragacanth (GT) for determination of histamine dihydrochloride (HDC). Initially, CNPs were prepared in one step by hydrothermal synthesis from a GT aqueous solution. Then, MP coated CNPs (MP-CNPs) were formed by anchoring the MP layer on the surface of CNPs via a sol-gel process. This fluorimetric sensor has the characteristics of both constituents (MP and CNPs) at the same time. It has high selectivity, which is a definite advantage of the MP and also has a high fluorescence intensity due to the presence of CNPs. The novel sensor was used to assay the HDC synthetic and biological samples. The fluorescence intensity of the MP-CNPs decreased linearly by increasing HDC concentration in the range of 0.7- $18.5~\mu $ gL−1, with a detection limit of $0.17~\mu $ g $\text{L}^{-1}$ . The precision of the method for 4.6 and $12.2~\mu $ gL−1 histamine dihydrochloride (HDC) was obtained as 6.8% and 4.3% (n = 3), respectively. The selectivity study showed that this sensor has a high selectivity, which is due to the presence of size-selective cavities and selective interactions on fluorosensor. Furthermore, the suggested method was successfully applied to recognize histamine biological samples with a recovery of 96-103%.
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