Abstract
AbstractThe aim of this paper is to explore the therapeutic contribution of graphene oxide (GO) to new sono/photosensitizers through sono/photochemical studies for the first time. For this purpose, new zinc (II) phthalocyanine bearing 3‐chloro‐4‐fluorophenoxy 2 was synthesized and then its GO‐based composites were prepared by non‐covalently coating ZnPc 2 on the graphene oxide surface. The photoactivity of these materials was compared and discussed in terms of their potential ability to be used in photosensitizer in photodynamic therapy (PDT) and sono‐photodynamic therapy (SPDT). In these application areas, GO can serve as photosensitizer carrier, while ZnPc 2 can be acting as PDT/SPDT agent. Therefore, phthalocyanine composites containing different percentages of graphene oxide by weight (wt.% GO) were prepared. SEM (scanning electron microscopy) results supported the interaction between GO and ZnPc 2. In the sono‐photochemical study, both ZnPc 2 and its composites gave very higher ΦΔ values than the photochemical study. The sono‐photochemical ΦΔ values were found to be 0.928 for 0 wt.% GO, 0.869 for 0.25 wt.% GO, 0.891 for 0.50 wt.% GO, 0.868 for 1 wt.% GO, 0.908 for 3 wt.% GO, 0.845 for 5 wt.% GO and 0.851 for 10 wt.% GO, respectively. According to obtained results, these materials could be promise as good photosensitizers for both the photochemical study and the sono‐photochemical study due to their very high singlet oxygen generation.
Published Version
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