Novel glucose sensor with Au@Ag heterogeneous nanorods based on electrocatalytic reduction of hydrogen peroxide at negative potential

Abstract

A novel electrochemical glucose sensor based on Au@Ag heterogeneous nanorods (Au@Ag heterogeneous NRs) was developed. The Au@Ag heterogeneous NRs exhibited favorable electrocatalytic ability to reduce H2O2 at negative potential of about −0.6V (vs. SCE). Further, the glucose oxidase (GOx)/Au@Ag heterogeneous NRs modified electrode was constructed as a glucose sensor, which exhibited wide linear range of 0.02–10mM glucose in O2-saturated phosphate buffered saline (PBS) at an applied potential of −0.4V. Additionally, the glucose sensor showed good reproducibility and stability. Further, the proposed sensor showed good selectivity to common interferents (ascorbic acid, uric acid and dopamine), other saccharides, and 0.15M chloride ions, which could be applicable for real human serum sample analysis.